Welcome to Mega Man 2 GB. Mega Man pursues his archenemy, Dr. Wily, whose latest world conquest scheme involves the theft of an experimental time machine. Mega Man faces Wily and several of his past foes, as well as a new and enigmatic robot named Quint.

Dr. Wily used a stolen time machine to travel into the future and return with a number of reconstructed Robot Masters from the second and third NES titles. Wily brought back the future Mega Man, who had been converted into the evil robot Quint and armed with Sakugarne, a lethal cross between a jackhammer and a pogo stick.