In Dr Mario World House, you must assist Doctor Mario in curing young Toad of his horrible sickness. Dr. Mario is on a quest to find a treatment for the infection. You have to go throughout the mushroom kingdom in search of an antidote to this disease before it has a chance to spread and make everyone sick because the villain Wario plans to steal all of the cures. You'll need to go inside the houses to accomplish this, but before you do so, you'll have to deal with adversaries and groups of archers on a mission to stop you. Confront a wide variety of foes while searching for a remedy!